Brendan Lee Selected Research

Ornithine Carbamoyltransferase Deficiency Disease

9/2013	Vector sequences are not detected in tumor tissue from research subjects with ornithine transcarbamylase deficiency who previously received adenovirus gene transfer.
3/2009	High-frequency detection of deletions and variable rearrangements at the ornithine transcarbamylase (OTC) locus by oligonucleotide array CGH.
8/2008	Cross-sectional multicenter study of patients with urea cycle disorders in the United States.
7/2006	Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice.
10/2004	Developmental outcomes with early orthotopic liver transplantation for infants with neonatal-onset urea cycle defects and a female patient with late-onset ornithine transcarbamylase deficiency.
9/2004	Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus.
4/2004	Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients.
10/2003	Differential utilization of systemic and enteral ammonia for urea synthesis in control subjects and ornithine transcarbamylase deficiency carriers.

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Brendan Lee Research Topics

Disease

21	Inborn Urea Cycle Disorders 09/2016 - 12/2002
16	Osteogenesis Imperfecta (Lobstein Disease) 01/2022 - 12/2006
14	Hyperammonemia 01/2020 - 10/2004
10	Argininosuccinic Aciduria 01/2020 - 10/2004
9	Neoplasms (Cancer) 01/2021 - 09/2005
8	Ornithine Carbamoyltransferase Deficiency Disease 09/2013 - 10/2003
5	Fibrosis (Cirrhosis) 01/2020 - 10/2004
4	Osteoporosis 01/2021 - 12/2006
4	Muscle Hypotonia (Hypotonia) 01/2018 - 08/2002
4	Hypertension (High Blood Pressure) 10/2017 - 09/2009
3	Neoplasm Metastasis (Metastasis) 01/2021 - 02/2011
3	Inflammation (Inflammations) 01/2017 - 05/2003
3	Hypertrophy 05/2015 - 12/2005
3	Inborn Genetic Diseases (Disease, Hereditary) 03/2013 - 10/2007
3	Hemophilia A (Haemophilia) 07/2012 - 12/2007
3	Hyperargininemia 02/2011 - 10/2004
2	Developmental Disabilities (Developmental Disability) 01/2022 - 01/2021
2	Osteosarcoma (Osteogenic Sarcoma) 01/2020 - 04/2009
2	Liver Diseases (Liver Disease) 01/2020 - 09/2004
2	Scoliosis 05/2019 - 12/2018
2	type 6 Osteogenesis imperfecta 07/2018 - 12/2011
2	Ataxia (Dyssynergia) 01/2018 - 01/2012
2	Disease Progression 09/2017 - 01/2017
2	Infections 09/2016 - 12/2012
2	Contracture 09/2014 - 03/2011
2	Citrullinemia 08/2008 - 03/2005
2	Cartilage-hair hypoplasia 10/2006 - 12/2005
2	Thrombocytopenia (Thrombopenia) 03/2005 - 02/2002
1	Out-of-Hospital Cardiac Arrest 04/2021
1	Undiagnosed Diseases 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Congenital Abnormalities (Deformity) 11/2020
1	Lysinuric Protein Intolerance 01/2020
1	Insulin Resistance 01/2020
1	Obesity 01/2020
1	Hepatomegaly 01/2020
1	Tibial Fractures (Fracture, Tibial) 01/2020
1	Strudwick syndrome 01/2019
1	Craniofacial Abnormalities 01/2019
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2019

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2002
15	NitrogenIBA 01/2020 - 12/2002
12	Urea (Carbamide)FDA LinkGeneric 01/2020 - 12/2002
10	EnzymesIBA 05/2012 - 02/2002
9	AmmoniaIBA 07/2015 - 12/2002
8	Collagen Type I (Type I Collagen)IBA 01/2021 - 12/2006
6	CollagenIBA 01/2021 - 05/2002
5	glycerol phenylbutyrateIBA 03/2016 - 07/2010
5	Arginine (L-Arginine)FDA Link 11/2012 - 08/2008
4	Amino Acids FDA Link 01/2020 - 10/2005
4	OrnithineIBA 01/2020 - 07/2006
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 09/2009
4	ArginaseIBA 01/2018 - 10/2004
4	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 03/2007
4	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 09/2013 - 09/2004
4	Argininosuccinic AcidIBA 06/2013 - 10/2004
4	4-phenylbutyric acid (Buphenyl)FDA Link 06/2013 - 07/2010
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
3	Teriparatide (Parathar)FDA Link 01/2021 - 02/2014
3	alpha2 Subunit Collagen Type IIBA 11/2020 - 12/2008
3	Glutamine (L-Glutamine)FDA Link 07/2015 - 10/2003
3	Messenger RNA (mRNA)IBA 08/2014 - 09/2005
3	CitrullineIBA 03/2009 - 03/2007
2	RNA (Ribonucleic Acid)IBA 01/2021 - 12/2005
2	Apolipoproteins E (ApoE)IBA 01/2020 - 03/2004
2	Alanine Transaminase (SGPT)IBA 01/2020 - 03/2005
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 05/2012
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 01/2018
2	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2019 - 06/2014
2	Diphosphonates (Bisphosphonates)IBA 05/2019 - 12/2018
2	pigment epithelium-derived factorIBA 07/2018 - 12/2011
2	Protease Inhibitors (Protease Inhibitor)IBA 07/2018 - 12/2011
2	SerpinsIBA 07/2018 - 12/2011
2	Pharmaceutical PreparationsIBA 09/2016 - 06/2011
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 05/2002
2	Dietary ProteinsIBA 07/2015 - 02/2011
2	Antihypertensive Agents (Antihypertensives)IBA 05/2015 - 05/2012
2	Branched-Chain Amino AcidsIBA 02/2011 - 04/2004
2	phenylacetic acid (phenylacetate)FDA Link 02/2011 - 10/2008
2	Factor VIII (Coagulation Factor VIII)IBA 02/2011 - 12/2007
1	Estrogens (Estrogen)FDA Link 01/2021
1	Selective Estrogen Receptor Modulators (SERM)IBA 01/2021
1	Coat Protein Complex I (COPI)IBA 01/2021
1	Steroid Receptors (Steroid Receptor)IBA 01/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2021
1	arginyllysineIBA 01/2020
1	mitochondrial uncoupler BAM15IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	Liver GlycogenIBA 01/2020
1	Transaminases (Aminotransferases)IBA 01/2020
1	UbiquitinIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	Glycogen Phosphorylase (Phosphorylase, Glycogen)IBA 01/2020
1	CSN5i-3IBA 01/2020
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2019
1	CamptothecinIBA 01/2019

Therapy/Procedure

16	Therapeutics 01/2022 - 04/2004
3	Liver Transplantation 05/2012 - 10/2004
2	Drug Therapy (Chemotherapy) 01/2020 - 12/2017
1	Cardiopulmonary Resuscitation (CPR) 04/2021